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Somatostatin (sst) is a hormone - regulatory peptide with multiple and diverse role in the central nervous system, the gastrointestinal tract and other peripheral tissues. SST has inhibitory actions on various secretory and growth processes. Its actions are implemented via G-protein bound receptor family. The receptors (sstr1-5) bound with high afinity with natural sst, whereas synthetic analogues (created to overcome the limitation of short half-life of the natural sst) bound mainly to sstr 2, 3, and 5. Somatostatin receptors’ expression in human tumours in vivo & in vitro, in non-tumoural tissues and in vessels, provided the ground for intense research and important applications in the diagnosis and treatment, most characteristically in neuroendocrine tumours. The identification of somatostatin receptors in the liver experimentally (sinusoidal cells, Kupffer cells), in chronic liver diseases and in hepatocellular carcinoma – HCC) together with the clear value of sst in the treatment ...
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