Η προγνωστική αξία των πρωτεϊνών P53 και P21 σε ασθενείς με καρκίνο του προστάτη μετά από ριζική προστατεκτομή

Abstract

Objective: This study assesses the correlation of p53 immunoreactivity andp21 immunoreactivity with biochemical recurrence after radicalprostatectomy.Materials and Methods: P53 protein expression and p21 were evaluated on84 archival paraffin-embedded radical prostatectomy specimens. Patientswere divided into 2 groups for p533: patients with low (38/84, 45%) andpatients with high (46/84, 55%) p53 immunoreactivity and into 5 groups forp21. Patients with expression of p21<1%, patients with p21 expressionbetween 1 and 5%, patients with p21 expression between 5 and 10%,patients with p21 expression between 10 and 20% and finally patients withp21 expression over 20%. The results were correlated with Gleason score,DNA ploidy, stage and serum PSA. Kaplan-Meier biochemical recurrence freesurvival and Cox hazard-regression model were used for analysis.Results: Multivariate analysis revealed p53, DNA ploidy, Gleason score andstage to be independent prognostic factors in the order they are presented.Kaplan-Meier analysis showed a statistically significant difference inbiochemical recurrence when p53 high expression and DNA aneuploidy werecombined. P21 and PSA level according the previus analysis were notindependent prognostic factors. Conclusion: The results of this study suggest that stratification for p53expression, p21 expression and DNA ploidy status can provide additionalprognostic information for patients with prostate carcinoma after radicalprostatectomy.