A study of the metabolic pathways affected by gestational diabetes mellitus: comparison with type 2 diabetes
Abstract
Introduction: Gestational diabetes mellitus (GDM), the metabolic disease that occurs in pregnant women and increases the risk for the development of diabetes remains incompletely understood. Metabolomics provides essential input into the etiology and pathogenesis of disease states and contribute to the discovery of biomarkers for an early and accurate detection. Nuclear magnetic resonance (NMR) spectroscopy is a key platform for the measurement of the metabolome has been previously used to define metabolic signatures associated with in intact serum/plasma with limited ability to identify metabolites and elucidate the corresponding metabolic pathways. Aim: In the present study, we used NMR-based metabolic analysis of the macromolecules free-serum of GDM women to increase the number of quantified metabolites for a more accurate characterization of the altered metabolic pathways leading to GDM and to examine their similarity with those associated with DM2. Methods: Sixty-two Caucasian wom ...
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