Genetical association studies in sleep apnea
Abstract
Obstructive sleep apnea syndrome (OSAS) is a pathological condition which disturbs the biological phenomenon of sleep and is the leading cause of breathing sleep disordered breathing. Obstructive sleep apnea syndrome is present in 5-6% of the general adult population of the Western world and the risk of developing the disease is 2-3 times greater in men compared to women and increases progressively with age. The most important predisposing factor for developing the syndrome is obesity, whereas smoking, alcohol consumption and congestion of the nasal cavity has been reported as further risk factors. OSAS is diagnosed by a polysomnographic study of nocturnal sleep and the resulting apnea hypopnea index indicates the severity of the syndrome. The most serious implications of OSAS are daytime sleepiness, the increased risk of cardiovascular disease, whilst the disorder is many times the hidden cause of sudden death, unexplainable hypertension or even inexplicable road accidents. Some cytok ...
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