| ND | 5comprised 10 patients (6 male, 4 female, m.a. 51,2±7,25 years), who were treated with pindolol and group D comprised 10 patients (6 male, 4 female, m.a. 52,1±9,36 years), who were treated with verapamil. The echocardio-Doppler evaluation was performed both at rest and at the peak of test. Left ventricular dimensions were obtained from two dimensionally guided M-mode tracings using the criteria of the American Society of Echocardiography. ...
The aim of this study is to evaluated the changes in hypertrophy, in systolic and diastolic function of left ventricular in hypertensives patients who were treated with different antihypertensives agents. 40 hypertensive patients (24male, 16 female mean age 52,05 +8,23 years) with left ventricular hypertrophy were divided in four groups. Group A comprised 10 patients (6 male, 4 female, m.a. 51,5±7,68 years), who were treated with lisinopril, group B comprised 10 patients (6 male, 4 female, m.a. 53,4±8,38 years), who were treated with atenolol, group C comprised 10 patients (6 male, 4 female, m.a. 51,2±7,25 years), who were treated with pindolol and group D comprised 10 patients (6 male, 4 female, m.a. 52,1±9,36 years), who were treated with verapamil. The echocardio-Doppler evaluation was performed both at rest and at the peak of test. Left ventricular dimensions were obtained from two dimensionally guided M-mode tracings using the criteria of the American Society of Echocardiography. Left ventricular peak filling rates and filling rate integrals were measured by a pulsed Doppler technique. Blood pressure regulation obtained in all patients. In group A patients decreased LV mass, LVEDd, end-systolic stress and increased EF, SF, in rest and stress were observed with statistical significance. In group B patients decreased LV mass in 6 months therapy, endsystolic stress and EF were observed with statistical significance. In group C patients decreased LV mass in 6 months therapy, LV mass in 4 months therapy and endsystolic stress were observed with statistical significance. Finally in group D patients decreased LV mass, LV mass in 4 months therapy and end-systolic stress and increased EF were observed with statistical significance. Diastolic indexes improved in all groups patients. From this thesis the following conclusions can be made: In lisinopril treated patients early left ventricular regression primarily due to the effect of the lisinopril and secondary due to control of the blood pressure Hemodynamic variation in atenolol, pindolol and verapamil treated patients need more time to cause regression in hypertrophic heart muscle of hypertensive patients. The optimal hypertensive therapy causing early and intensive LV regression, is the one causing smoother blood pressure normalization, applied in the beginning stages. Although the LV mass reduces, the antihypertensive agents without negative inotropic action improve systolic LV function. When reduction of the blood pressure is achieved, the negative inotropic effect of the atenolol does not degrade the patients systolic LV fuction in rest and in stress. In general improvement of the LV systolic function observed during stress is due to reduced need of the heart muscle in oxygen. Although the systolic LV function is often normal in early stages in hypertensive patients LV diastolic function are impair in hypertensive patients. Therefore in patients with normal systolic function, congestive heart disease symptoms can be observed. Early improvement of the LV diastolic function independently of the hypertensive agent used is due to decrease of the blood pressure, heart rate, oxygen demand, improvement coronary flow and suppression of theRAAS.
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Όλα τα τεκμήρια στο ΕΑΔΔ προστατεύονται από πνευματικά δικαιώματα.
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| Όλα τα τεκμήρια στο ΕΑΔΔ προστατεύονται από πνευματικά δικαιώματα.
| The effect of antihypertensive treatment on the structural and functional parameters of the left ventricle in hypertensive patients
| | Συγγραφέας | Στυλιάδης, Ιωάννης (Πατρώνυμο: Γεώργιος) | | Ημερομηνία | 2001 |
| Ίδρυμα | Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ). Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής. Τομέας Παθολογίας. Κλινική Β' Παθολογική |
| Εξεταστική επιτροπή | Λευκός Νικόλαος
Παρχαρίδης Γεώργιος
Λαζαρίδης Αναστάσιος
Παπαδημητρίου Μενέλαος
Τουρκαντώνης Αχιλλέας
Ζιάκας Γεώργιος
Ζαμπούλης Χρύσανθος |
| Επιστημονικό πεδίο | Ιατρική και Επιστήμες Υγείας ➨ Κλινική Ιατρική ➨ Καρδιολογία και Καρδιοαγγειακά νοσήματα |
| Λέξεις-κλειδιά | Αρτηριακή υπέρταση; Αριστερή κοιλία, Αναδιαμόρφωση; Αντιϋπερτασικά φάρμακα; Αριστερή κοιλία, Υπερτροφία; Αριστερή κοιλία, λειτουργία | | Χώρα | Ελλάδα |
| Γλώσσα | Ελληνικά |
| Άλλα στοιχεία | εικ., πιν., σχημ., γραφ. |
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