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THE ROLE OF T3 IN ADULT BRAIN TISSUE IS NOT QUITE CLEAR. THE EXPERIMENTAL APPROACH WAS TO PERTURB CNS ACTIVITY AND DETERMINE THE CHARACTERISTICS OF T3 RECEPTOR BINDING. THE PERTURBATION OF BRAIN FUNCTION WAS ACHIEVED UTILIZING DRUGSKNOWN TO ALTER BRAIN ACTIVITY: PENTYLENETETRAZOLE, DIAZEPAM, CHLORAL HYDRATEAND LICL. IN OUR STUDY WE OBSERVED THAT; PENTYLENETETRAZOLE (4 HRS AFTER ADMINISTRATION) INCREASES THE NUMBER OF T3 BINDING SITES (BMAX), WITHOUT ANY CHANGES IN AFFINITY. DIAZEPAM (24 HOURS AFTER ADMINISTRATION) DECREASES THE DENSITY OF T3 BINDING SITES WITH NO CHANGES IN AFFINITY. THE ADMINISTRATION OF HYPNOTIC CHLORAL HYDRATE DECREASES BMAX, WHEN THE ANIMALS ARE IN THE CONDITION OF NARCOSIS-SLEEP (ONE HOUR AND THIRTY MINUTES AFTER ADMINISTRATION OF THE DRUG) WHILE NO CHANGES WAS OBSERVED WHEN THE ANIMALS WERE ALLOWED TO AWAKE (TWOHOURS AND THIRTY MINUTES AFTER DRUG ADMINISTRATION). A SINGLE INJECTION OF LICL INCREASES THE BINDING OF T3 AND THIS INCREASE WAS O ...
THE ROLE OF T3 IN ADULT BRAIN TISSUE IS NOT QUITE CLEAR. THE EXPERIMENTAL APPROACH WAS TO PERTURB CNS ACTIVITY AND DETERMINE THE CHARACTERISTICS OF T3 RECEPTOR BINDING. THE PERTURBATION OF BRAIN FUNCTION WAS ACHIEVED UTILIZING DRUGSKNOWN TO ALTER BRAIN ACTIVITY: PENTYLENETETRAZOLE, DIAZEPAM, CHLORAL HYDRATEAND LICL. IN OUR STUDY WE OBSERVED THAT; PENTYLENETETRAZOLE (4 HRS AFTER ADMINISTRATION) INCREASES THE NUMBER OF T3 BINDING SITES (BMAX), WITHOUT ANY CHANGES IN AFFINITY. DIAZEPAM (24 HOURS AFTER ADMINISTRATION) DECREASES THE DENSITY OF T3 BINDING SITES WITH NO CHANGES IN AFFINITY. THE ADMINISTRATION OF HYPNOTIC CHLORAL HYDRATE DECREASES BMAX, WHEN THE ANIMALS ARE IN THE CONDITION OF NARCOSIS-SLEEP (ONE HOUR AND THIRTY MINUTES AFTER ADMINISTRATION OF THE DRUG) WHILE NO CHANGES WAS OBSERVED WHEN THE ANIMALS WERE ALLOWED TO AWAKE (TWOHOURS AND THIRTY MINUTES AFTER DRUG ADMINISTRATION). A SINGLE INJECTION OF LICL INCREASES THE BINDING OF T3 AND THIS INCREASE WAS OBSERVED 1, 4, 24 HRS AFTER ITS ADMINISTRATION. DAILY LICL ADMINISTRATION FOR 7 DAYS HAD THE SAME EFFECT. THE INCREASE IN T3 BINDING REFLECTS AN INCREASE IN BMAX, WHEREAS CHANGESIN KD WERE NOT OBSERVED. LICL ALSO DECREASED T3 TRANSPORT. IN CONCLUSION, OUR RESULTS SHOW THAT IN ADULT BRAIN THYROID HORMONE RECEPTOR DENSITY CHANGES WITH ALTERATIONS IN DRUG INDUCED BRAIN ACTIVITY, AN EFFECT THAT MAY REFLECT ALTERATIONS IN GENE EXPRESSION CODING T3 RECEPTORS (C-ERBA). (ABSTRACT TRUNCATED)
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