Molecular study in interleukins and metalloproteinases genes which are associated with inherited predisposition for oral squamous cell carcinoma

Abstract

Aim: Prevention and early diagnosis of many deadly diseases are of great importance for the safeguarding of the health status and lives of people at risk, worldwide. Cancer is a major health problem, which needs further investigation in order to be addressed in a more effective treatment. In particular, oral squamus cell carcinoma (OSCC) is the sixth more common malignancy worldwide. Recent studies have revealed that several factors previously correlated to angiogenesis, thrombosis, and DNA repairing are associated to OSCC. Serum or saliva levels of interleukins IL-1β,-4,-6,-8,-10, tumor necrosis factors TNF-α,-β, matrix metalloproteinases MMP-1,-3, -7, -9, -13 and tissue inhibitor of MMP-2 (TIMP-2) have been associated with increased risk for the development of OSCC. The present case-control study examines possible interactions between functional DNA polymorphisms, that affect gene expression and levels of the above mentioned seven interleukins and six metalloproteinases, as well as ...
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DOI
10.12681/eadd/27226
Handle URL
http://hdl.handle.net/10442/hedi/27226
ND
27226
Alternative title
Μοριακή μελέτη γονιδίων ιντερλευκινών και μεταλλοπρωτεϊνασών που σχετίζονται με κληρονομική προδιάθεση για καρκίνο του στόματος
Author
Serefoglou, Zoe (Father's name: Charalambos)
Date
2011
Degree Grantor
National and Kapodistrian University of Athens
Committee members
Βαϊρακτάρης Ελευθέριος
Πατσούρης Ευστράτιος
Περρέα Δέσποινα
Κουράκλης Γρηγόριος
Τσιγκρής Χρήστος
Καβαντζάς Νικόλαος
Λάζαρης Ανδρέας
Discipline
Medical and Health Sciences
Medical Biotechnology
Keywords
Oral squamous cell carcinoma; Single nucleotide polymorphisms; Cytokines; Interleukins; Metalloproteinases; Tissue inhibitor of metalloproteinase-2; Genetic association studies; Gene polymorphisms
Country
Greece
Language
Greek
Description
187 σ., tbls., fig.
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