Screening Peri-και μετεμμηνοπαυσιακών γυναικών για την πρώιμη ανίχνευση ενδομήτριας παθολογίας

Abstract

THE PURPOSE OF THE STUDY WAS TO INVESTIGATE THE EFFECTIVENESS OF THE COMBINED PROCEDURE INCLUDING TRANSVAGINAL ULTRASOUND AND ASPIRATION ENDOMETRIAL BIOPSYFOR THE EARLY DETECTION OF ENDOMETRIAL ABNORMALITY. 432 ASYMPTOMATIC WOMEN >40 YEARS OLD, UNDERWENT PELVIC EXAMINATION AND ENDOMETRIAL THICKNESS MEASUREMENT (229 POSTMENOPAUSAL, 203 PERIMENOPAUSAL). WHEN THE ENDOMETRIUM WAS >3MM FOR POSTMENOPAUSAL AND >5MM FOR PERIMENOPAUSAL. A MEASUREMENT OF ENDOMETRIAL VOLUME AND AN ENDOMETRIAL BIOPSY WERE PERFORMED. HISTOLOGIC RESULT WAS NON DIAGNOSTIC IN 16 CASES. FROM A TOTAL OF 59 POSTMENOPAUSAL WOMEN, 1 CASE OF ADENOCARCINOMA, 11 CASES OF ENDOMETRIAL HYPERPLASIA AND 4 POLYPS WERE DETECTED BY BIOPSY WHICH ALSO REVEALED 11 CASES OF ENDOMETRIAL HYPERPLASIA, 1 POLYP AND1 ENDOMETRIAL INFECTION IN THE GROUP OF 80 PERIMENOPAUSAL WOMEN. IN ALL THE ABNORMAL POSTMENOPASUAL ENDOMETRIA THICKNESS AND VOLUME WERE >9MM AND 3ML RESPECTIVELY AND FOR THIS CUTOFF LIMITS TVS WOULD HAVE 100% SENSITIVITY 90.6% SPECIFICITY AND 80% PPV FOR THICKNES AND 100% SENSITIVITY, 97.4% SPECIFICITY AND 94.1 PPV FOR VOLUME IN DETECTING ENDOMETRIAL ABNOMARLITY. ALL THE ABNORMALPERIMENOPAUSAL WOMEN HAD THICKNESS >13MM AND VOLUME >5ML AND FOR THIS CUTOFFLIMITS TVS WOULD HAVE 100% SENSITIVITY, 71.6% SPECIFICITY AND 40.6% PPV FORTHICKNESS AND 100% SENSITIVITY, 97% SPECIFICITY AND 86.6% PPV FOR VOLUME. THE COMBINATION OF ENDOMETRIAL THICKNESS AND VOLUME MEASUREMENTS AND ASPIRATIONBIOSPY WHEN THICKNESS IS >9MM OR VOLUME >3ML COULD (ABSTRACT TRUNCATED).

ΣΚΟΠΟΣ ΤΗΣ ΜΕΛΕΤΗΣ ΕΙΝΑΙ Η ΑΞΙΟΛΟΓΗΣΗ ΤΟΥ ΣΥΝΔΥΑΣΜΟΥ ΔΙΑΚΟΛΠΙΚΗΣ ΥΠΕΡΗΧΟΓΡΑΦΙΑΣ ΚΑΙ ΕΝΔΟΜΗΤΡΙΑΣ ΒΙΟΨΙΑΣ ΓΙΑ ΤΗΝ ΠΡΩΙΜΗ ΑΝΙΧΝΕΥΣΗ ΕΝΔΟΜΗΤΡΙΑΣ ΠΑΘΟΛΟΓΙΑΣ. ΤΟΥΛΙΚΟ ΑΠΟΤΕΛΕΣΑΝ 432 ΑΣΥΜΠΤΩΜΑΤΙΚΕΣ ΓΥΝΑΙΚΕΣ ΗΛΙΚΙΑΣ >40 ΕΤΩΝ (229 ΜΕΤΕΜΜΗΝΟΠΑΥΣΙΑΚΕΣ ΚΑΙ 203 ΠΕΡΙΕΜΜΗΝΟΠΑΥΣΙΑΚΕΣ) ΠΟΥ ΥΠΟΒΛΗΘΗΚΑΝ ΣΕ ΓΥΝΑΙΚΟΛΟΓΙΚΗ ΕΞΕΤΑΣΗΚΑΙ ΥΠΕΡΗΧΟΓΡΑΦΗΜΑ. ~ΤΑΝ ΤΟ ΕΝΔΟΜΗΤΡΙΟ ΗΤΑΝ >3MM ΓΙΑ ΤΙΣ ΜΕΤΕΜΜΗΝΟΠΑΥΣΙΑΚΕΣ ΚΑΙ >5MM ΓΙΑ ΤΙΣ ΠΕΡΙΕΜΜΗΝΟΠΑΥΣΙΑΚΕΣ ΜΕΤΡΗΘΗΚΕ ΥΠΕΡΗΧΟΓΡΑΦΙΚΑ Ο ΟΓΚΟΣ ΤΟΥ ΕΝΔΟΜΗΤΡΙΟΥ ΚΑΙ ΑΚΟΛΟΥΘΗΣΕ ΑΝΑΡΡΟΦΗΤΙΚΗ ΒΙΟΨΙΑ ΑΥΤΟΥ.