Η ΑΝΑΙΜΙΑ ΣΤΗ ΡΕΥΜΑΤΟΕΙΔΗ ΑΡΘΡΙΤΙΔΑ

Abstract

THE AIM OF THE STUDY IS TO EVALUATE: 1)THE FREQUENCY, TYPE AND SEVERITY OF ANEMIA, 2)ITS CORRELATION WITH DESEASE ACTIVITY AND 3)THE POSSIBLE PATHOGENE- SIS OF ANEMIA. METHODS: TO EVALUATE THE FREQUENCY OF ANEMIA IN RHEUMATOID ARTHRITIS (RA), A SAMPLE OF 100 PATIENTS WHO LIVE IN IOANNINA DISTRICT, WAS STUDIED. THEY UNDER- WENT A COMPLETE PHISICAL EXAMINATION. THE FOLLOWING TESTS WERE PERFORMED: HEMATOLOGIC, BIOCHEMICAL [MEASUREMENT OF FERUM, TIBC, FERRITIN,VITAMIN B12, FOLIC ACID AND ERYTHROPOIETIN (EPO)], MICROBIOLOGICAL, IMMUNOLOGIC, COOMBS TEST, ANTIERYTHROPOIETIN ANTIBODIES. IN MOST PATIENTS SERUM TNFΑ, IL-6 AND IL-10 WERE MEASURED. BONE MARROW BIOPSY WAS PERFORMED IN 39 RAPATIENTS, WHILE BONE MARROW OF 18 RA PATIENTS AND 13 HEALTHY DONORS WAS USEDFOR BONE MARROW CULTURES. IN THESE CULTURES THE DEVELOPMENT OF BFU-E AND CFU-E, WITH AND WITHOUT ADDITION OF TNF-Α, IL-1Β, IL-6, IL-10, TGF-Β AND TNF-ΑPLUS IL-10, WAS EVALUATED. RESULTS: THE FREQUENCY OF ANEMIA WAS 27,4%. IT WAS MILD, NORMOCHROMIC NORMO- CYTIC AND IT WAS CORRELATED WITH DESEASE ACTIVITY. THE MOST COMMON TYPE WAS ANEMIA OF CHRONIC DISEASE (ACD). ANEMIC PATIENTSHAD ELEVATED SERUM LEVELS OF EPO WHILE THERE WERE NO DETECTABLE ANTIERYTHROPOIETIN ANTIBODIES. SERUM LEVELS OF TNF-Α, IL-Β AND IL-6 WERE ELEVATED IN ANEMIC PATIENTS. THEY ALSO INHIBITED PROLIFERATION OF ERYTHROID UNITS IN RA PATIENTS AND HEALTHY DONORS. SERUM CONCENTRATIONS OF IL-10 WERE LOW IN RA PATIENTS. ABSTRACT TRANSACTED.

ΣΚΟΠΟΣ ΤΗΣ ΜΕΛΕΤΗΣ: ΕΙΝΑΙ ΝΑ ΚΑΘΟΡΙΣΤΟΥΝ: 1)Η ΣΥΧΝΟΤΗΤΑ, ΤΟ ΕΙΔΟΣ ΚΑΙ Η ΣΟΒΑ-ΡΟΤΗΤΑ ΤΗΣ ΑΝΑΙΜΙΑΣ, 2)Η ΣΥΣΧΕΤΙΣΗ ΤΗΣ ΜΕ ΤΗΝ ΕΝΕΡΓΟΤΗΤΑ ΤΗΣ ΝΟΣΟΥ ΚΑΙ 3)Η ΠΙΘΑΝΗ ΑΙΤΙΟΠΑΘΟΓΕΝΕΙΑ ΤΗΣ. ΜΕΘΟΔΟΛΟΓΙΑ: ΓΙΑ ΤΟΝ ΚΑΘΟΡΙΣΜΟ ΤΗΣ ΣΥΧΝΟΤΗΤΑΣ ΤΗΣ ΑΝΑΙΜΙΑΣ ΣΤΗ ΡΕΥΜΑΤΟΕΙΔΗ ΑΡΘΡΙΤΙΔΑ (PA), ΜΕΛΕΤΗΘΗΚΕ ΕΝΑ ΔΕΙΓΜΑ 100 ΑΤΟΜΩΝΠΟΥ ΚΑΤΟΙΚΟΥΝ ΣΤΟ ΝΟΜΟ ΙΩΑΝ- ΝΙΝΩΝ. ΕΠΙΣΗΣ, ΜΕΛΕΤΗΘΗΚΑΝ 105 ΑΝΑΙΜΙΚΟΙ ΚΑΙ 127 ΜΗ ΑΝΑΙΜΙΚΟΙ ΑΣΘΕΝΕΙΣ ΜΕ PA ΣΤΟΥΣ ΟΠΟΙΟΥΣ ΕΓΙΝΑΝ: ΠΛΗΡΗΣ ΚΛΙΝΙΚΗ ΕΞΕΤΑΣΗ