Η ΠΡΟΓΝΩΣΤΙΚΗ ΣΗΜΑΣΙΑ ΤΗΣ ΑΓΓΕΙΟΒΡΙΘΕΙΑΣ ΣΤΗΝ ΑΚΤΙΝΟΘΕΡΑΠΕΥΤΙΚΗ ΑΝΤΙΜΕΤΩΠΙΣΗ ΤΟΥ ΑΔΙΑΦΟΡΟΠΟΙΗΤΟΥ ΚΑΡΚΙΝΩΜΑΤΟΣ ΤΟΥ ΕΠΙΦΑΡΥΓΓΑ (ΛΕΜΦΟΕΠΙΘΗΛΙΩΜΑ)

Abstract

VASCULARITY IS ONE OF THE PROGNOSTIC PARAMETERS IN CERVICAL CARCINOMA OF THE UTERUS AND IN LARYNGEAL CARCINOMA. IN OUR STUDY, WE ATTEMPTED TO CORRELATE THE GRADE OF VASCULARITY OF LYMPHOEPITHELIOMA AND THE PROGNOSIS OF THIS TUMOUR. ADDITIONALY, WE LOOKED FOR THE POSSIBILITY OF INDIVIDUALIZATION OF RADIOTHERAPY IN CONJUNCTION WITH THE GRADE OF VASCULARITY OF THE TUMOUR. OUR MATERIAL WAS CONSISTED OF 27 CASES OF LYMPHOEPITHELIOMA, WHICH HAD BEEN FOLLOWED UP FOR MORE THAN THREE YEARS. ALL PATIENTS WERE TREATED WITH RADIOTHERAPY ONLY. SECTIONS WERE CUT FROM PARAFIN BLOCKS AND WERE STAINED WITH HEMATOXYLIN- EOSIN. MASSON-TRICHROME AND PEROXIDASE FOR FACTOR VIII. MICROSCOPIC EVALUATION OF THE VASCULARITY, WAS DONE AT STANDARD 200 X MAGNIFICATION. THE PATIENTS WERE CLASSIFIED, ACCORDINGTO THE TIME OF SURVIVAL IN THREE GROUPS. IN THE FIRST GROUP, THE PATIENTS HAD SURVIVED LESS THAN 1 YEAR, IN THE SECOND GROUP FROM 1 TO 3 YEARS AND IN THE THIRD GROUP FOR MORE THAN 3 YEARS. THE CORRELATION BETWEEN SURVIVAL AND GRADE OF VASCULARITY WAS EXAMINED. IT WAS FOUND, THAT PATIENTS WITH TUMOURS WITH HIGH DEGREE OF VASCULARITY LIVED FOR MORE THAN THREE YEARS WHEREAS PATIENTS WITH TUMOURS WITH LOW DEGREE OF VASCULARITY LIVED LESS THAN ONE YEAR. IN CONCLUSION THE CASES WITH POOR VASCULARITY SHOWED LOW SURVIVAL RATE WHEREAS THE CASES WITH RICH VASCULARITY SHOWED HIGHER SURVIVAL RATE. TAKING INTO ACCOUNT, THAT VASCULARITY REFLECTS THE DEGREE OF OXYGENATION OF THE TUMOUR AND THE TUMOURS WITH LOW OXYGENATION ARE, USUALLY, RADIORESISTANT, THE KNOWLEDGE OF THE DEGREE OF VASCULARITYIS OF IMPORTANCE. THIS KNOWLEDGE COULD BE OF HELP IN SELECTING CASES, IN WHICHTHE USE OF SENSITIZERS WILL PROBABLY INCREASE THE EFFECTIVENESS OF RADIOTHERAPY. IT IS OBVIOUS, THAT THESE CASES ARE THE ONES WITH POOR VASCULARITY. THUS THEAPPLICATION OF SENSITIZERS IN THESE CASES, WHICH HAVE POOR PROGNOSIS IS EXPECTED TO HAVE POSITIVE RESULTS IN THE MAJORITY OF THEM.

Η ΑΓΓΕΙΟΒΡΙΘΕΙΑ ΑΠΟΤΕΛΕΙ ΠΡΟΓΝΩΣΤΙΚΗ ΠΑΡΑΜΕΤΡΟ ΣΤΟ ΚΑΡΚΙΝΩΜΑ ΤΟΥ ΤΡΑΧΗΛΟΥ ΤΗΣ ΜΗΤΡΑΣ ΚΑΙ ΣΤΟ ΚΑΡΚΙΝΩΜΑ ΤΟΥ ΛΑΡΥΓΓΑ. ΣΤΗ ΜΕΛΕΤΗ ΜΑΣ ΕΠΙΧΕΙΡΗΣΑΜΕ ΝΑ ΣΥΣΧΕΤΙΣΟΥΜΕ ΤΟ ΒΑΘΜΟ ΑΓΓΕΙΟΒΡΙΘΕΙΑΣ ΣΤΟ ΑΔΙΑΦΟΡΟΠΟΙΗΤΟ ΚΑΡΚΙΝΩΜΑ ΤΟΥ ΕΠΙΦΑΡΥΓΓΑ (ΛΕΜΦΟΕΠΙΘΗΛΙΩΜΑ) ΜΕ ΤΗΝ ΠΡΟΓΝΩΣΗ ΤΟΥ. ΑΚΟΜΑ, ΑΝΑΖΗΤΗΣΑΜΕ ΤΗ ΔΥΝΑΤΟΤΗΤΑ ΕΞΑΤΟΜΙΚΕΥΣΗΣ ΤΗΣ ΑΚΤΙΝΟΘΕΡΑΠΕΙΑΣ, ΣΕ ΣΥΝΑΡΤΗΣΗ ΜΕ ΤΟ ΒΑΘΜΟ ΑΓΓΕΙΟΒΡΙΘΕΙΑΣ ΤΟΥ ΟΓΚΟΥ. ΤΟ ΥΛΙΚΟ ΜΑΣ ΑΠΟΤΕΛΕΣΑΝ 27 ΠΕΡΙΠΤΩΣΕΙΣ ΑΔΙΑΦΟΡΟΠΟΙΗΤΟΥ ΚΑΡΚΙΝΩΜΑΤΟΣ ΤΟΥ ΕΠΙΦΑΡΥΓΓΑ, ΓΙΑ ΤΙΣ ΟΠΟΙΕΣ ΥΠΗΡΧΕ ΠΑΡΑΚΟΛΟΥΘΗΣΗ ΓΙΑ ΠΕΡΙΣΣΟΤΕΡΑ ΑΠΟ 3 ΧΡΟΝΙΑ. ΣΕ ΟΛΟΥΣ ΤΟΥΣ ΑΣΘΕΝΕΙΣ Η ΜΟΝΑΔΙΚΗ ΘΕΡΑΠΕΥΤΙΚΗ ΑΝΤΙΜΕΤΩΠΙΣΗ ΗΤΑΝ Η ΑΚΤΙΝΟΒΟΛΙΑ ΜΕ CO. (ΠΕΡΙΚΟΠΗ)