Η ΕΥΑΙΣΘΗΣΙΑ ΤΩΝ ΖΥΜΟΜΥΚΗΤΩΝ CANDIDA "IN VITRO"ΕΙΣ ΤΑ ΑΝΤΙΣΗΠΤΙΚΑ

Abstract

THIS STUDY DEALS WITH THE SENSITIVITY OF THE YEASTS OF THE GENUS CANDIDA I.E. C.ALBICANS, C.TROPICALIS, C.PSEUDOTROPICALIS, C.KRUSEI, C.PARAKRUSEI, C.PULCHERIMA, C.PELLICULOSA, C.STELLATOIDEA, C.GUILLERMONDI IN VITRO TO ANTICEPTIC AGENTS. THESE ANTISEPTICS ARE AT THE PRESENT TIME IN CIRCULATION IN THE GREEK PHARMACEUTIC MARKET. THEY ARE: PHISOHEX LIQUID, BETADINE SCRUB SOLUTION, MERFEN TINCTURE, INCOSEPT LIQUID, INCOOULON, BORIC ACID 4%, PHENOL 1% AND FORMALDEYDE SOLUTION 34.8% SUITABLY DILUTED. THE DETERMINATION OF THE ANTISEPTIC ACTIVITY OF THE ABOVE AGENTS WAS PERFORMED ON PIECES OF MOCKET. THE ACTIVITY ON EACH AGENT WAS STUDIED ON VARIOUS SPECIES OF CANDIDA AFTER 15', 30', 60', 120'. THE RESULTS ARE TABULATED IN 10 TABLES. THE FOLLOWING CONCLUSIONS WERE DRAWN: THE PHISOHEX HAD NO EFFECT WHATSOVER ON THE YEASTS OF THE SPECIES CANDIDA ALBICANS,C.TROPICALIS, C.PSEUDOTROPICALIS, C.PELLICULOSA, C.GUILLERMONDI, C.STELLATOIDEA. ON THE REMAINING SPECIES, C.KRUSEI, C.PARAKRUSEI AND C.PULCHERIMA HAD INHIBITORY ACTIVITY (TABLE 10). PHENOL 1% DESTROYED MOST CANDIDA SPECIES APART FROM C.KRUSEI, C.PARAKRUSEI, C.PELLICULOSA, C.GUILLERMONDI, C.PSEUDOTROPICALIS WHERE IT HAD INHIBITORY ACTIVITY OF VARIOUS DEGREES. THE DILUTIONS 10% AND 20% OF DETTOL HAD SIMILAR WITH THE UNDILUTED DETTOL EFFECT ON THE ABOVE MENTIONED SPECIES OF CANDIDA. THE ANTICEPTIC BETADINE SCRUB SOLUTION ON ALL THE TESTED DILUTIONS 10%, 20%, 30% AS WELL AS UNDILUTED HAD INTENSE ANTISEPTIC ACTIVITY ON ALL THE TESTED CANDIDA SPECIES. SIMILARLY THE ANTISEPTICS MERFEN, (ABSTRACT TRUNCATED)

ΕΙΣ ΤΗΝ ΠΑΡΟΥΣΑΝ ΕΡΓΑΣΙΑΝ ΕΜΕΛΕΤΗΘΗ Η ΕΥΑΙΣΘΗΣΙΑ ΟΛΩΝ ΤΩΝ ΖΥΜΟΜΥΚΗΤΩΝ ΤΟΥ ΓΕΝΟΥΣ CANDIDA ΗΤΟΙ ΤΩΝ C.ALBICANS, C.TROPICALIS, C.PSEUDOTROPICALIS, C.KRUSEI,C. PARAKRUSEI, C.PULCHERIMA, C.PELLICULOSA, C.STELLATOIDEA, C.GUILLERMONDI IN VITRO ΕΝΑΝΤΙ 9 ΑΝΤΙΣΗΠΤΙΚΩΝ ΤΑ ΟΠΟΙΑ ΚΥΚΛΟΦΟΡΟΥΝ ΕΙΣ ΤΟ ΕΛΛΗΝΙΚΟΝ ΕΜΠΟΡΙΟΝ. ΤΑΥΤΑ ΕΙΝΑΙ ΤΑ ΕΞΗΣ: 1) PHISOHEX LIQUID, 2) BETADINE SCRUB SOLUTION, 3) MERFEN TINCTURE, 4) INCOSEPT LIQUID, 5) INCOOULON, 6) ΒΟΡΙΚΟΝ ΟΞΥ 4%,7) ΦΑΙΝΟΛΗ 1%, 8) DETTOL, 9) ΔΙΑΛΥΜΑ ΦΟΡΜΑΛΔΕΥΔΗΣ 34.8% ΚΑΤΑΛΛΗΛΩΣ ΑΡΑΙΩΘΕΝ. ΔΙΑ ΤΗΝ ΑΝΑΖΗΤΗΣΙΝ ΤΗΣ ΑΝΤΙΣΗΠΤΙΚΗΣ ΔΡΑΣΕΩΣ ΑΥΤΩΝ ΕΧΡΗΣΙΜΟΠΟΙΗΘΗ Η ΜΕΘΟΔΟΣ ΤΗΣ ΜΟΚΕΤΤΑΣ (Ο. ΜΑΡΣΕΛΟΥ - ΚΙΝΤΗ - Α. ΒΕΛΕΓΡΑΚΗ, 1980). ΕΜΕΛΕΤΗΘΗ ΔΗΛΑΔΗ Η ΔΡΑΣΙΣ ΕΝΟΣ ΕΚΑΣΤΟΥ ΑΝΤΙΣΗΠΤΙΚΟΥ ΕΠΙ ΤΩΝ ΔΙΑΦΟΡΩΝ ΣΤΕΛΕΧΩΝ ΤΩΝ ΖΥΜΟΜΥΚΗΤΩΝ ΕΠΙ 15', 30', 60', 120' ΕΙΣ ΤΕΜΑΧΙΑ ΜΟΚΕΤΤΑΣ. ΤΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΣΥΓΚΕΝΤΡΩΝΟΝΤΑΙ ΕΙΣ ΔΕΚΑ ΠΙΝΑΚΑΣ ΚΑΙ ΕΙΝΑΙΠΕΡΙΛΗΠΤΙΚΩΣ ΤΑ ΕΞΗΣ: 1) ΤΟ PHISOHEX ΟΥΔΕΜΙΑΝ ΔΡΑΣΙΝ ΕΙΧΕΝ ΕΠΙ ΤΩΝ C. ALBICANS, C.TROPICALIS, C.PSEUDOTROPICALIS, C.PELLICULOSA, C.GUILLERMONDI, C.STELLATOIDEA. ΕΙΣ ΤΑΣ ΥΠΟΛΟΙΠΟΥΣ ΕΙΧΕΝ ΑΝΑΣΤΑΛΤΙΚΗΝ ΔΡΑΣΙΝ (ΠΙΝΑΞ 10). 2) Η ΦΑΙΝΟΛΗ 1%ΕΙΧΕΝ ΑΠΟΛΥΜΑΝΤΙΚΗΝ ΔΡΑΣΙΝ, ΔΗΛΑΔΗ ΚΑΤΕΣΤΡΕΨΕ ΤΑΣ ΠΕΡΙΣΣΟΤΕΡΑΣ CANDIDA ΠΛΗΝ ΤΩΝ C.KRUSEI, C.PARAKRUSEI, C.PELLICULOSA, C.GUILLERMONDI ΤΩΝ ΟΠΟΙΩΝ ΑΠΛΩΣ ΑΝΕΣΤΕΙΛΕ ΤΗΝ ΑΝΑΠΤΥΞΙΝ ΑΛΛΟΤΕ ΠΕΡΙΣΣΟΤΕΡΟΝ ΚΑΙ ΑΛΛΟΤΕ ΟΛΙΓΟΤΕΡOΝ. 3) ΤΟ DETTOL ΠΥΚΝΟ ΕΞΟΛΟΘΡΕΥΣΕ ΤΑΣ C.ALBICANS, C.TROPICALIS, C.PSEUDOTROPICALIS, C.PULCHERIMA, C.STELLATOIDEA, C.GUILLERMONDI ΕΙΣ ΟΛΟΥΣ ΤΟΥΣ ΧΡΟΝΟΥΣ, ΕΝΩ ΤΑΣ ΥΠΟΛΟΙΠΟΥΣ 2ΚΑΤΕΣΤΡΕΨΕ ΜΟΝΟΝ ΕΙΣ ΤΟΝ ΧΡΟΝΟΝ ΤΩΝ 15'. ΑΙ ΑΡΑΙΩΣΕΙΣ 10% ΚΑΙ 20% ΤΟΥ ΑΝΩΤΕΡΩΑΝΤΙΣΗΠΤΙΚΟΥ (ΠΕΡΙΚΟΠΗ ΠΕΡΙΛΗΨΗΣ)