Oxidative stress and the DNA damage response/repair network in systemic autoimmune diseases

Abstract

Systemic autoimmune diseases comprise an heterogenous group and are characterized by aberrant chronic immune activation against self-antigens, production of autoantibodies and tissue injury. Although their pathophysiology remains unclear, several lines of evidence suggest that the imbalance between the oxidant and antioxidant cellular systems after exposure to deleterious stimuli, termed oxidative stress, is shown to be involved. Reactive oxygen and nitrogen species are key mediators of oxidative stress and may damage cellular DNA. To protect the genome, cells have developed several DNA repair mechanisms, composing the DNA damage response and repair network (DDR/R). On the other hand, chronological age, associated with a decline of the immune system functionality, leading to increased susceptibility to cancer and autoimmunity. Herein, we aimed to examine whether systemic autoimmunity is associated with aberrations in oxidative stress formation and DNA damage accumulation, as well as wh ...
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DOI
10.12681/eadd/56064
Handle URL
http://hdl.handle.net/10442/hedi/56064
ND
56064
Alternative title
Το οξειδωτικό στρες και το δίκτυο κυτταρικής απόκρισης στην βλάβη του DNA σε ασθενείς με συστηματικά αυτοάνοσα νοσήματα
Author
Ntouros, Panagiotis-Ioannis (Father's name: Andreas)
Date
2024
Degree Grantor
National and Kapodistrian University of Athens
Committee members
Σφηκάκης Πέτρος
Γοργούλης Βασίλειος
Σουλιώτης Βασίλειος
Τεκτονίδου Μαρία
Λυμπερόπουλος Ευάγγελος
Μαυραγάνη Κλειώ
Φραγκούλης Γιώργος
Discipline
Medical and Health SciencesBasic Medicine ➨ Immunology
Medical and Health SciencesClinical Medicine ➨ Rheumatology
Keywords
Oxidative stress; DNA damage response/repair (DDR/R) network; Systemic autoimmune diseases; Rheumatology; DNA repair mechanisms
Country
Greece
Language
English
Description
im., tbls., fig., ch.
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