Study of epigenetic mechanisms in the chemoresistance of triple negative breast cancer
Abstract
Breast cancer is the most frequently diagnosed malignancy in women worldwide and the heterogeneity of the disease is an obstacle for the development of effective treatments that will lead to the definitive elimination of these tumors. Triple negative breast cancer (TNBC) is characterized by the absence of estrogen, progesterone and human epidermal growth factor 2 receptors, and is the most aggressive type of breast cancer with poor survival and prognosis. Due to the lack of identified molecular targets, chemotherapy is the standard treatment for TNBC, but, despite a good initial response, many patients will develop resistance and tumor recurrence. TNBC tumors possess a wide range of chemoresistance mechanisms,including deregulated epigenetic mechanisms. Understanding these mechanisms could lead to the development of new targeting approaches that may be more effective against chemoresistant cells. In the present study, we have developed and characterized two paclitaxel-resistant TNBC ce ...
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(Release date: 11/2025)
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