Study of epigenetic mechanisms in the chemoresistance of triple negative breast cancer

Abstract

Breast cancer is the most frequently diagnosed malignancy in women worldwide and the heterogeneity of the disease is an obstacle for the development of effective treatments that will lead to the definitive elimination of these tumors. Triple negative breast cancer (TNBC) is characterized by the absence of estrogen, progesterone and human epidermal growth factor 2 receptors, and is the most aggressive type of breast cancer with poor survival and prognosis. Due to the lack of identified molecular targets, chemotherapy is the standard treatment for TNBC, but, despite a good initial response, many patients will develop resistance and tumor recurrence. TNBC tumors possess a wide range of chemoresistance mechanisms,including deregulated epigenetic mechanisms. Understanding these mechanisms could lead to the development of new targeting approaches that may be more effective against chemoresistant cells. In the present study, we have developed and characterized two paclitaxel-resistant TNBC ce ...
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DOI
10.12681/eadd/55069
Handle URL
http://hdl.handle.net/10442/hedi/55069
ND
55069
Alternative title
Μελέτη επιγενετικών μηχανισμών στη χημειοανθεκτικότητα του τριπλά αρνητικού καρκίνου του μαστού
Author
Kordias, Dimitrios (Father's name: Georgios)
Date
2023
Degree Grantor
University of Ioannina
Committee members
Μαγκλάρα Αγγελική
Κούκλης Παναγιώτης
Λεονταρίτης Γεώργιος
Μάουρι Ντάβιντε
Γεωργιάδου Μαρία
Κωλέττας Ευάγγελος
Παπαμαρκάκη Θωμαΐς
Discipline
Medical and Health SciencesOther Medical Sciences ➨ Research and Experimental medicine
Keywords
Triple negative breast cancer; Chemoresistance; Epigenetics
Country
Greece
Language
Greek
Description
im., tbls., fig., ch.
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