HISTOPATHOLOGICAL LESIONS IN THE BRAIN, LIVER AND KIDNEYS CAUSED BY TOXICAL DOSES OF PHENYTOIN IN RABBITS
Abstract
IN THIS STUDY 32 WHITE NEW ZEALAND RABBITS WERE EXAMINED FOR TOXIC EFFECTS OF PHENYTOIN, IN THE BRAIN, LIVER AND KIDNEYS IN RELATION TO THE CONCENTRATION OF PHENYTOIN IN THEIR BLOOD. ALL MEASUREMENTS WERE MADE USING R.I.A. METHOD. THE RABBITS WERE DIVIDED INTO THREE GROUPS, A,B AND C. PHENYTOIN WAS GIVEN INTRAMUSCULARY IN GROUPS A AND B IN DOSES OF 100 MG AND 200 PER KG BODY WEIGHT RESPECTIVELY AND 250 MG PER KG BODY WEIGHT IN GROUP C INTRAPERITONEALLY DAILY FOR A PERIOD OF 20 DAYS. IN ORDER TO RECORD CLINICAL SYMPTOMS, OBSERVATIONS OF THE RABBITSWERE MADE EVERY DAY FOR SEVERAL HOURS AND MEASUREMENTS OF THE CONCENTRATION OFPHENYTOIN IN THE BLOOD WERE MADE, IN SAMPLES TAKEN EVERY WEEK. (SHORTENED)
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